Human Cytomegalovirus-Encoded miR-US25-1 Aggravates the Oxidised Low Density Lipoprotein-Induced Apoptosis of Endothelial Cells

Figure 1

HCMV infection promoted miR-US25-1 level in vivo or in vitro. (a) The expression of miR-US25-1 was examined in blood samples of normal subjects with (𝑛=28) or without (𝑛=10) HCMV positive. (b) The expression of miR-US25-1 was examined in blood samples of atherosclerosis subjects with (𝑛=32) or without (𝑛=12) HCMV positive. (c) Correlation of miR-US25-1 expression with plasma pp65 mRNA level. (d) and (e) Growth curve of HCMV in EAhy926 or HEF cells, MOI = 0.1. (f) HCMV infection upregulates miR-US25-1 level in EAhy926 cells. All experiments for (d)–(f) were performed in triplicate independently. Statistical significance was showed as ^∗𝑃<0.05 and ^∗∗𝑃<0.01.

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