Network of microRNAs-mRNAs Interactions in Pancreatic Cancer

Table 3

Genes target that are regulated with more than one microRNA and are displayed in the network.

Number	Target gene	Description	GO annotation	microRNAs	𝑃 value
1	ACVR2B*	Active in A receptor, type IIB	Muscle growth	hsa-miR-181b; hsa-miR-103; hsa-miR-210; hsa-miR-107	0.011748; 0.018318; 0.021035; 0.028112
2	AP3S2	Adaptor-related protein; complex 3, sigma 2 subunit	Protein transporter activity	hsa-miR-24; hsa-miR-210	0.000145; 0.010804
3	C22orf29	Chromosome 22 open reading frame 29	Protein binding; play a key role in apoptotic signaling activity	hsa-miR-103; hsa-miR-107	0.001947; 0.00305
4	C22orf46	Chromosome 22 open reading frame 46	Transcription regulation	hsa-miR-221; hsa-miR-181d; hsa-miR-181b	0.000716; 0.002848; 0.003748
5	DYRK2	Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2	Translation insulin regulation of translation and DNA damage	hsa-miR-103; hsa-miR-210	0.024406; 0.027992
6	GFRA1*	GDNF family receptor alpha 1; development of EGFR signaling pathway and axon guidance	Integrin binding and receptor binding	hsa-miR-221; hsa-miR-210	0.011847; 0.04776
7	GPR107	G protein-coupled receptor 107		hsa-miR-222; hsa-miR-221	0.012316; 0.037447
8	HOOK3	Hook microtubule-tethering protein 3	Attach to microtubule, and more divergent C-terminal domains, which mediate binding; to organelles	hsa-miR-222; hsa-miR-221; hsa-miR-181b	0.000872; 0.002815; 0.014215
9	IRGQ	Immunity-related GTPase; family, Q		hsa-miR-24; hsa-miR-222	0.011954; 0.027394
10	KSR2	Kinase suppressor of ras 2	Protein serine/threonine kinase activity and MAP-kinase scaffold activity	hsa-miR-24; hsa-miR-222	0.030872; 0.048884
11	MTHFR*	Methylenetetrahydrofolate reductase (NAD(P)H)	Methylenetetrahydrofolate reductase (NADPH) activity and modified amino acid binding	hsa-miR-103; hsa-miR-107	0.044941; 0.03749
12	N4BP1	NEDD4 binding protein 1	Protein binding	hsa-miR-222; hsa-miR-221	0.001158; 0.003722
13	NXF1	Nuclear RNA export factor 1	Nucleocytoplasmic transporter activity and nucleotide binding; mRNA processing and transport of mature mRNAs derived from intronless transcripts	hsa-miR-24; hsa-miR-31	0.005296; 0.046764
14	PGPEP1	Pyroglutamyl-peptidase I	Cysteine-type peptidase activity	hsa-miR-31	0.000891
				hsa-miR-210	0.003034
15	PLEKHM3	Pleckstrin homology domain containing, family M, and member 3	Phospholipid binding and metal ion binding	hsa-miR-222	0.005244
				hsa-miR-221	0.016343
				hsa-miR-146a	0.046599
16	TSPAN14	Tetraspanin 14		hsa-miR-24	0.000255
				hsa-miR-210	0.01834
17	UBN2	Ubinuclein 2		hsa-miR-24	0.005656
				hsa-miR-222	0.013163
18	ZBTB42	Zinc finger and BTB domain containing 42	DNA binding and zinc ion binding; transcriptional repressor	hsa-miR-181d; hsa-miR-181b	0.025341; 0.032903

∗Target gene that are common on Tables 2 and 3.