Effects of Various Antiepileptics Used to Alleviate Neuropathic Pain on Compound Action Potential in Frog Sciatic Nerves: Comparison with Those of Local Anesthetics

Figure 6

Comparison of the effects of antiepileptics (lamotrigine and carbamazepine) on frog sciatic nerve CAPs with those of local anesthetics (levobupivacaine, lidocaine, ropivacaine, procaine, cocaine, and tetracaine). The peak amplitude of CAP recorded from sciatic nerve fibers treated with each of the chemicals at various concentrations for 20 min, relative to control, which was plotted against its concentration. The data of local anesthetics except for levobupivacaine (whose data were reproduced from Figure 5(c)(B)) were taken from previous reports [11–14]. The curves for the local anesthetics were drawn according to the Hill equation, while those for lamotrigine and carbamazepine, shown by black lines, were reproduced from Figures 1(d) and 2(a)(C), respectively.