𝜶-Mangostin Suppresses the Viability and Epithelial-Mesenchymal Transition of Pancreatic Cancer Cells by Downregulating the PI3K/Akt Pathway

Figure 2

α-Mangostin induces apoptosis of pancreatic cancer cells. (a) Panc-1 and BxPC-3 cells were treated with α-mangostin (0 μM, 8 μM, or 16 μM) for 24 h. Apoptotic cells were evaluated by Annexin V-FITC/PI staining and flow cytometry. Representative FACS plots are shown. (b) Apoptosis rate of the early and late apoptosis was quantified by flow cytometry. ^∗𝑃<0.05 compared with controls. (c) Protein levels of Bcl-2 and cleaved caspase-3 were detected by Western blotting with β-actin as loading control.

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