NGF Accelerates Cutaneous Wound Healing by Promoting the Migration of Dermal Fibroblasts via the PI3K/Akt-Rac1-JNK and ERK Pathways

<table>Wound closure after NGF treatment in rat. (a) Representative photographs of skin full-thickness excisional wounds in rat treated topically every other day with saline control or 10, 20, or 40 <i>μ</i>g/mL of NGF for 8, 10, 12, and 14 days after wounding. (b) The rate of wound healing after different concentrations of NGF treatment. <svg height="17.825001" id="M2" style="vertical-align:-3.13504pt" version="1.1" viewbox="0 0 69.150002 17.825001" width="69.150002" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg>, compared to saline-treated control; <svg height="19.65" id="M3" style="vertical-align:-3.13504pt" version="1.1" viewbox="0 0 70.224998 19.65" width="70.224998" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg>, compared to 40 <i>μ</i>g/mL NGF group; <svg height="10.925" id="M4" style="vertical-align:-0.10033pt" version="1.1" viewbox="0 0 36.237499 10.925" width="36.237499" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg>.</table>

BioMed Research International

fig1

Figure 1

Figure 1: NGF Accelerates Cutaneous Wound Healing by Promoting the Migration of Dermal Fibroblasts via the PI3K/Akt-Rac1-JNK and ERK Pathways 