NGF Accelerates Cutaneous Wound Healing by Promoting the Migration of Dermal Fibroblasts via the PI3K/Akt-Rac1-JNK and ERK Pathways

<table>The effect of NGF on the proliferation and migration of human skin fibroblasts. (a) Cultured human dermal fibroblasts were incubated with different concentrations of NGF protein (0, 10, 100, and 1000 ng/mL) for 24 h, and cell proliferation was assessed by MTT assay. (b) Wound-healing assay of cultured human skin fibroblasts treated with saline or 100 ng/mL NGF for 24 h. (c) The migration rate of cultured fibroblasts after wounding is expressed as migration distance/time (<i>μ</i>m/h). <svg height="17.825001" id="M16" style="vertical-align:-3.13504pt" version="1.1" viewbox="0 0 69.150002 17.825001" width="69.150002" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg>, compared to control group.</table>

BioMed Research International

fig5

Figure 5

Figure 5: NGF Accelerates Cutaneous Wound Healing by Promoting the Migration of Dermal Fibroblasts via the PI3K/Akt-Rac1-JNK and ERK Pathways 