The Mcm2-7 Replicative Helicase: A Promising Chemotherapeutic Target

Table 2

Small molecule inhibitors of Mcm2-7.

Inhibitor	Phenotype	Structure	IC50	Subunits targeted	Reference
Ciprofloxacin	Blocks in vitro helicase activity, cellular growth		~600 μM (both for yeast/human cell cytotoxicity and for purified Mcm2-7 helicase activity)	Mcm2-7	[63]
Heliquinomycin	Blocks in vitro helicase activity, arrests growth of cancer cells		~3 μM (human Mcm467 helicase activity and cellular DNA synthesis)	Mcm467	[121, 122]
Trichostatin A	HDAC inhibitor, induces apoptosis		<1 μM (human cell cytotoxicity and Mcm2 protein levels)	Mcm2 protein levels	[123]
Widdrol	Growth inhibition, DNA damage, G1 arrest, downregulation of Mcms		60–217 μM (human cell cytotoxicity and Mcm protein expression)	Mcm 2-7; Mcm4 (early) protein levels	[124, 125]