Systemic Treatment with Strontium Ranelate Accelerates the Filling of a Bone Defect and Improves the Material Level Properties of the Healing Bone
Table 1
Effect of 4, 8, or 12 weeks of SrRan or vehicle administration on micro-CT analysis of trabecular bone healing a bone defect in adult female rat tibiae.
Trabecular bone
Treatment
Time of treatment
4 weeks
8 weeks
12 weeks
Conn. D (1)
vehicle
40.56 ± 11.08
14.70 ± 4.49
22.86 ± 6.74
SrRan
75.24 ± 15.15
50.73 ± 7.64*
74.87 ± 11.62*
TbN (1/mm)
vehicle
4.38 ± 0.33
3.75 ± 0.14
3.91 ± 0.16
SrRan
4.60 ± 0.22
4.20 ± 0.10°
4.41 ± 0.17
TbTh (1/mm)
vehicle
0.066 ± 0.005
0.062 ± 0.003
0.064 ± 0.005
SrRan
0.075 ± 0.005
0.081 ± 0.002#
0.082 ± 0.002*
SMI (1)
vehicle
2.78 ± 0.27
3.30 ± 0.24
2.88 ± 0.30
SrRan
2.25 ± 0.28
2.14 ± 0.13*
1.91 ± 0.23°
Averages ± SEM; Mann-Whitney; , , versus time-matched vehicle.
