Systemic Treatment with Strontium Ranelate Accelerates the Filling of a Bone Defect and Improves the Material Level Properties of the Healing Bone
Table 2
Effect of 4, 8, or 12 weeks of SrRan or vehicle administration on micro-CT analysis of a circular band of 0.45 mm wide selected on the peripheral portion of a bone defect in adult female rat tibiae.
Trabecular bone bordering defect
Treatment
Time of treatment
4 weeks
8 weeks
12 weeks
BV/TV (%)
vehicle
16.86 ± 4.61
14.16 ± 1.45
14.50 ± 1.86
SrRan
26.57 ± 4.06°
22.84 ± 1.77°
27.86 ± 2.92*
TbN (1/mm)
vehicle
5.00 ± 0.37
4.40 ± 0.11
4.46 ± 0.28
SrRan
5.66 ± 0.40
4.99 ± 0.21
5.21 ± 0.18°
TbTh (mm)
vehicle
0.072 ± 0.007
0.082 ± 0.009
0.074 ± 0.003
SrRan
0.083 ± 0.004
0.084 ± 0.002
0.084 ± 0.003°
TbSp (mm)
vehicle
0.217 ± 0.015
0.231 ± 0.006
0.248 ± 0.014
SrRan
0.189 ± 0.014
0.216 ± 0.010
0.196 ± 0.008*
SMI (1)
vehicle
2.487 ± 0.454
2.767 ± 0.137
2.505 ± 0.116
SrRan
1.640 ± 0.368
1.706 ± 0.177°
1.544 ± 0.251°
Averages ± SEM; Mann-Whitney; ; versus time-matched vehicle.
