Systemic Treatment with Strontium Ranelate Accelerates the Filling of a Bone Defect and Improves the Material Level Properties of the Healing Bone

Table 3

Effect of 4, 8, or 12 weeks of SrRan administration on material level properties of cortical bone healing a bone defect in adult female rat tibiae.

Cortical bone	Treatment	Time of treatment
		4 weeks	8 weeks	12 weeks
Modulus (gPa)	Vehicle	8.31 ± 0.39	10.55 ± 0.37	14.87 ± 0.43
	SrRan	11.39 ± 0.60^#	11.00 ± 0.71	14.40 ± 0.67
Hardness (mPa)	Vehicle	275.1 ± 17.8	291.3 ± 13.9	477.4 ± 23.0
	SrRan	394.5 ± 31.3*	347.5 ± 29.3	482.8 ± 29.9
Working Energy (pJ)	Vehicle	1970.3 ± 96.4	1933.2 ± 68.4	3076.4 ± 102.6
	SrRan	2561.6 ± 113.1^#	2269.5 ± 142.3°	3105.5 ± 123.3

Averages ± SEM; 2-way ANOVA; ; ; versus vehicle.