Systemic Treatment with Strontium Ranelate Accelerates the Filling of a Bone Defect and Improves the Material Level Properties of the Healing Bone

Table 4

Effect of 4, 8, or 12 weeks of SrRan administration on material level properties of trabecular bone healing a bone defect in adult female rat tibiae.

Trabecular bone	Treatment	Time of treatment
		4 weeks	8 weeks	12 weeks
Modulus (gPa)	vehicle	9.17 ± 0.39	11.20 ± 0.53	13.50 ± 0.49
	SrRan	11.51 ± 0.58*	11.66 ± 0.60	13.85 ± 0.43
Hardness (mPa)	vehicle	356.1 ± 24.2	507.31 ± 27.22	588.38 ± 19.48
	SrRan	449.6 ± 28.6°	534.51 ± 29.04	640-67 ± 20.06
Working Energy (pJ)	vehicle	2224.8 ± 135.9	2769.7 ± 139.4	3365.7 ± 104.2
	SrRan	2725.6 ± 145.8°	3006.3 ± 152.8	3758.2 ± 97.4*

Averages ± SEM; 2 ways ANOVA; ; versus vehicle.