Research Article
Aetiology of Bacteraemia as a Risk Factor for Septic Shock at the Onset of Febrile Neutropaenia in Adult Cancer Patients
Table 3
Univariate analysis of the risk factors for septic shock (SS) at the time of febrile neutropenia (FN) in hospitalised cancer patients.
| | Variable | SS group () | Non-SS group () | OR (95% CI) | value |
| | Age, years, mean ± SD | | | 1.00 (0.96–1.04) | 0.87 | | Female sex | 10 (58.8) | 42 (42.8) | 1.90 (0.66–5.41) | 0.22 | | Haematological neoplasm | 13 (76.4) | 83 (84.6) | 0.58 (0.16–2.04) | 0.40 | | Relapsing underlying disease | 10 (58.8) | 49 (50.0) | 1.42 (0.50–4.05) | 0.50 | | Clinical comorbidity | 2 (11.7) | 34 (34.6) | 0.25 (0.05–1.16) | 0.07 | | High-dose chemotherapy regimens* | 5 (29.4) | 47 (47.9) | 0.45 (0.14–1.38) | 0.16 | | Oral mucositis | | | | | | Grade I | 4 (23.5) | 29 (29.5) | 0.76 (0.21–2.71) | 0.68 | | Grade II | 2 (11.7) | 8 (8.1) | 1.38 (0.25–7.63) | 0.70 | | Grade III | 1 (5.8) | 5 (5.1) | 1.11 (0.11–10.66) | 0.92 | | Grade IV | 1 (5.8) | 6 (6.1) | 0.92 (0.09–8.63) | 0.94 | | ANC at the time of diagnosis of FN, mean ± SD | | | 0.99 (0.99–1.00) | 0.36 | | Profound neutropenia at the time of diagnosis of FN† | 9 (52.9) | 43 (43.8) | 1.43 (0.51–4.04) | 0.49 | | BSI involving Gram-positive bacteria | 6 (39.2) | 40 (40.8) | 0.79 (0.27–2.31) | 0.66 | | BSI involving Gram-negative bacteria | 14 (82.3) | 60 (61.2) | 2.96 (0.79–10.97) | 0.10 | | Polymicrobial BSI | 5 (29.4) | 7 (7.1) | 5.41 (1.48–19.79) | 0.01 | | MDR BSI | 4 (23.5) | 34 (34.6) | 0.57 (0.17–1.91) | 0.37 | | BSI involving Gram-positive MDR bacteria | 3 (17.6) | 24 (24.4) | 0.66 (0.17–2.49) | 0.54 | | BSI involving Gram-negative MDR bacteria | 1 (5.8) | 11 (11.2) | 0.49 (0.05–4.09) | 0.51 | | BSI by Escherichia coli | 11 (64.7) | 37 (37.7) | 3.02 (1.03–8.85) | 0.04 | | BSI by coagulase-negative staphylococci | 4 (23.5) | 32 (32.6) | 0.63 (0.19–2.10) | 0.45 | | BSI by Klebsiella pneumoniae | 3 (17.6) | 10 (10.2) | 1.88 (0.46–7.70) | 0.37 | | BSI by Pseudomonas aeruginosa | 2 (11.7) | 9 (9.1) | 1.31 (0.25–6.70) | 0.73 | | BSI by viridans streptococci | 3 (17.6) | 5 (5.1) | 3.98 (0.85–18.54) | 0.07 |
|
|
Data presented as (%) unless otherwise indicated. ANC: Absolute neutrophil count; BSI: bloodstream infection; HSCT: haematopoietic stem cell transplantation; MDR: multidrug-resistant; OR: odds ratio; 95% CI: 95% confidence interval; SD: standard deviation. *Induction chemotherapy or HSCT; †ANC < 100 cells/mm³.
|
