Biological and Molecular Effects of Small Molecule Kinase Inhibitors on Low-Passage Human Colorectal Cancer Cell Lines

Table 2

IC₅₀ values of vemurafenib, perifosine, regorafenib, and trametinib (BrdU incorporation assay).

	Vemurafenib (M)	Perifosine (M)	Regorafenib (M)	Trametinib (nM)
HROC18	8.3	15.4	1.3	39.9
HROC24	0.8	6.7	4.6	5.1
HROC43	9.9	8.7	5.3	89.2
HROC46	12.7	#	2.4	252

#: no inhibitory effects on BrdU incorporation under experimental conditions.