Iminoflavones Combat 1,2-Dimethyl Hydrazine-Induced Aberrant Crypt Foci Development in Colon Cancer

Table 1

Preliminary cytotoxicity assessment in various cell lines.

Treatment	IC50 in μM (mean ± SEM)
	HCT-116	MCF-7	MDA-MB-231	EAC
Doxorubicin	2.88 ± 0.02	4.43 ± 0.34	1.77 ± 0.1	25.05 ± 0.9
IMF-2	105.2 ± 0.9	ND	ND	ND
IMF-4	132.1 ± 1.2	ND	ND	ND
IMF-5	41.79 ± 0.67	42.53 ± 0.78	59.13 ± 0.76	110.2 ± 0.21
IMF-8	2.78 ± 0.10	13.51 ± 0.13	6.38 ± 0.24	36.6 ± 3.2

Values are reported as mean ± SEM of three readings in triplicate; ND: not determined.
HCT-116, MCF-7, and MDA-MB-231 by SRB assay (exposure: 48 h).
EAC by Trypan blue exclusion assay (exposure: 4 h).