Effect of Experimentally Induced Hepatic and Renal Failure on the Pharmacokinetics of Topiramate in Rats

<table>Serum creatinine (a) and aspartate transaminase (AST) (b) in control and experimentally induced hepatic or renal failure rats. Data presented are mean ± SE in 16 rats. <svg height="17.825001" id="M24" style="vertical-align:-3.13504pt" version="1.1" viewbox="0 0 99.4375 17.825001" width="99.4375" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg>, significantly different from control group.</table>

BioMed Research International

fig1

Figure 1

Figure 1: Effect of Experimentally Induced Hepatic and Renal Failure on the Pharmacokinetics of Topiramate in Rats 