Local Packing Density Is the Main Structural Determinant of the Rate of Protein Sequence Evolution at Site Level
Figure 3
Local packing density versus solvent accessibility as determinants of site-specific evolutionary rates. Points above (below) the diagonal are proteins for which WCN () correlates better than (WCN) with the site-specific rates of amino acid substitution as estimated using the phylogenetic-based approach ConSurf (CS). The percentages of points above and below the diagonals are shown.
