The Parameters of Transcutaneous Electrical Nerve Stimulation Are Critical to Its Regenerative Effects When Applied Just after a Sciatic Crush Lesion in Mice
Figure 2
Sciatic nerve ultrathin transverse sections (7,000x magnification). (a) Control group (intact unstimulated nerve) showing large myelinated fibers; (b) nontreated group (unstimulated injured nerve) showing a fiber with dissolute axoplasm (asterisk), myelin disruption (dashed, white arrow). (c) Low-TENS group (damaged nerve with low-frequency electrical stimulation), where myelinated fibers were well preserved, showing a normal aspect; (d) High-TENS group (damaged nerve with high-frequency stimulation), with a fiber presenting myelin disruption culminating in complete demyelination (dashed, white arrow). Magnification bar: 2 μm.
