Oral and Intraperitoneal Administration of Quercetin Decreased Lymphocyte DNA Damage and Plasma Lipid Peroxidation Induced by TSA In Vivo
Figure 3
Total (a) and individual (b) concentrations of quercetin (Q) and its metabolites in tumor tissues of tumor-bearing mice with various treatments. Thirty-six male nude mice were injected with A549 cells and after 3 weeks were treated with TSA alone (0.5 mg/kg body weight) or in combination with Q (OL and OH, Q administered orally at 20 and 100 mg/kg body weight, respectively; IL and IH, Q administered intraperitoneally at 2 and 10 mg/kg body weight, resp.) for 16 weeks as described in Section 2. The control group was administered the vehicle only. After the mice were sacrificed, total and individual concentrations of Q, quercetin-3-glucuronide (Q3G), and quercetin-3′-sulfate (Q3′S) in the tumor tissues were determined. Values are expressed as means ± SD () and those of the same compound not sharing a common letter are significantly different ().
