Review Article

Nigral Iron Elevation Is an Invariable Feature of Parkinson’s Disease and Is a Sufficient Cause of Neurodegeneration

Table 1

Reports of quantifiable iron in PD SN.

Iron measurement techniqueFe in PD SN (% control)Reference

ICP-MS135[116]
SP176[117]
SP177[118]
AAS107[119]
ICP-MS133[120]
ICP-MS130[121]
X-Ray Microprobe analysis340[122]
SP150[123]
Laser microprobe analysis145[124]
ICPMS156[125]
Colorimetry82[126]
X-Ray absorption fine structure201[127]
Electron probe X-Ray microanalysis 
coupled with cathodoluminescence spectroscopy
200[128]
AAS144[96]
X-Ray fluorescence155[129]
ICP-MS140[110]
AAS139[26]

Average159.5

ICPMS: inductively coupled plasma mass spectrometry; SP: spectrophotometry; AAS: atomic absorption spectrometry.