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BioMed Research International
Volume 2014 (2014), Article ID 586501, 8 pages
http://dx.doi.org/10.1155/2014/586501
Research Article

Cerebrovascular and Neuroprotective Effects of Adamantane Derivative

1Zakusov Institute of Pharmacology RAMS, 8 Baltiyskaya Street, Moscow 125315, Russia
2Yerevan State Medical University after Mkhitar Heratsi, 2 Koryun Street, 0025 Yerevan, Armenia

Received 15 January 2014; Revised 12 February 2014; Accepted 13 February 2014; Published 20 March 2014

Academic Editor: Joen-Rong Sheu

Copyright © 2014 Ruben S. Mirzoyan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objectives. The influence of 5-hydroxyadamantane-2-on was studied on the rats’ brain blood flow and on morphological state of brain tissue under the condition of brain ischemia. The interaction of the substance with NMDA receptors was also studied. Methods. Study has been implemented using the methods of local blood flow registration by laser flowmeter, [3H]-MK-801binding, and morphological examination of the brain tissue. We used the models of global transient ischemia of the brain, occlusion of middle cerebral artery, and hypergravity ischemia of the brain. Results. Unlike memantine, antagonist of glutamatergic receptors, the 5-hydroxyadamantane-2-on does not block NMDA receptors but enhances the cerebral blood flow of rats with brain ischemia. This effect is eliminated by bicuculline. Under conditions of permanent occlusion of middle cerebral artery, 5-hydroxyadamantane-2-on has recovered compensatory regeneration in neural cells, axons, and glial cells, and the number of microcirculatory vessels was increased. 5-Hydroxyadamantane-2-on was increasing the survival rate of animals with hypergravity ischemia. Conclusions. 5-Hydroxyadamantane-2-on, an adamantane derivative, which is not NMDA receptors antagonist, demonstrates significant cerebrovascular and neuroprotective activity in conditions of brain ischemia. Presumably, the GABA-ergic system of brain vessels is involved in mechanisms of cerebrovascular and neuroprotective activity of 5-hydroxyadamantane-2-on.