In Vitro Dissolution and In Vivo Bioavailability of Six Brands of Ciprofloxacin Tablets Administered in Rabbits and Their Pharmacokinetic Modeling

Table 3

Compartmental analysis of ciprofloxacin from the tested products and the reference product after oral administration in rabbit.

Parameter	A	B	C	D	E	Ref
𝐴 (mg/L)	12.56±0.12	17.73±0.17	1.24±0.09	1.05±0.13	1.20±0.11	22.46±0.21
𝐵 (mg/L)	11.36±0.05	10.44±0.12	11.82±0.08	12.44±0.24	11.59±0.07	9.94±0.19^∗
Alpha (1/hr)	2.01±0.04	2.03±0.05	0.64±0.15	0.24±0.12	0.25±0.06	2.22±0.05
Beta (1/hr)	0.24±0.005	0.23±0.007	0.22±0.003	0.23±0.004	0.21±0.006	0.16±0.002^∗
K12 (1/hr)	0.57±0.02	0.62±0.03	0.01±0.006	0.07±0.003	0.01±0.007	0.77±0.102
K21 (1/hr)	1.16±0.24	1.28±0.32	0.63±0.13	0.01±0.003	0.24±0.093	1.35±0.052
AUC (hr·mg/L)	56.20±1.85	46.60±2.54^∗	52.92±2.48	74.53±3.57	61.15±4.25	62.23±3.27
Alpha_HL (hr)	0.37±0.01	0.34±0.05	1.84±0.03	1.56±0.06	3.63±0.02	0.31±0.04
Beta_HL (hr)	3.01±0.25	3.07±0.37	3.15±0.29	2.99±0.21	3.43±0.035	4.32±0.33^∗
V1_F (L)	29.20±2.54	29.90±2.96	41.73±3.51	41.80±3.21	40.62±3.24	30.41±3.75
CL_F (L/hr)	10.90±0.34	10.70±0.42	9.46±0.63	6.70±0.41	8.19±0.95	8.04±0.85
V2_F (L)	11.36±0.23	14.50±0.39	0.23±0.03	10.35±0.51	1.30±0.24	17.33±1.61
𝑇max (hr)	0.54±0.1	0.60±0.3	0.99±0.3	0.56±0.2	0.61±0.09	0.60±0.07
𝐶max (mg/L)	10.89±0.95	10.57±1.73	9.57±0.93	10.49±1.01	10.84±0.57	10.45±0.85

^∗𝑃<0.05.