Identification of MicroRNA as Sepsis Biomarker Based on miRNAs Regulatory Network Analysis

Figure 2

The distribution of NOD value was compared between known miRNA biomarkers and all miRNAs in database. Though we constructed miRNA-mRNA interactions network, the number of genes targeted exclusively by a specific microRNA can be computed. So each miRNA has a NOD value. Kolmogorov-Smirnov test (K-S test) was used to test whether two underlying one-dimensional probability distributions differ. The above boxplot really highlights the difference between two samples. The P value is 0.005 and illustrates that known miRNA biomarkers have more genes uniquely regulated by it.