Synthesis and In Vitro Inhibition Effect of New Pyrido[2,3-d]pyrimidine Derivatives on Erythrocyte Carbonic Anhydrase I and II

Table 1

Inhibitory effect of indolylchalcone (5a–g) and pyrido[2,3-d]pyrimidine derivatives (7a–k) on hCA I and hCA II.

Compound	hCA I; IC50 (𝜇M)	hCA II; IC50 (𝜇M)
5a	8.34	8.88
5b	7.42	10.35
5c	13.07	12.28
5d	8.20	8.26
5e	12.84	9.15
5f	10.87	9.31
5g	8.38	7.22
7a	16.29	19.42
7b	11.56	12.06
7c	21.09	31.10
7d	12.14	13.66
7e	6.79	8.06
7f	26.21	25.40
7g	7.61	7.57
7h	12.36	24.67
7i	8.72	8.14
7j	10.19	9.56
7k	22.30	26.68