Propofol Protects the Immature Rabbit Heart against Ischemia and Reperfusion Injury: Impact on Functional Recovery and Histopathological Changes

Table 2

Histological changes following ischemia and reperfusion.

	Light microscopy			Electron microscopy
	Clumping of nuclear chromatin	Intracellular edema	Interstitial edema	I-band in myocyte	(Mitochondrial changes)
					Dense material deposit	Clarity of matrix	Deformation of cristae
Control	2	2	3	1	2	2	1
2 g/mL Propofol	1	1	1	0	1	1	1
10 g/mL Propofol	3	2	2	1	3	3	2

The scale of 0 to 4 represents the degrees of each morphological change: 0, normal; 1, trivial; 2, mild; 3, moderate; and 4, severe.