Review Article
Acute Kidney Injury in Neonates: From Urine Output to New Biomarkers
Table 1
Comparison between AKI classification system in adults, older children, and newborns.
| | | Creatinine criteria | Urine output criteria | | | RIFLE | pRIFLE and nRIFLE | RIFLE | pRIFLE | nRIFLE |
| | Risk | Increased creatinine x1.5 or GFR decreases >25% | Increased creatinine x1.5 or GFR decreases >25% | UO ≤0.5 mL/kg/h × 6 h | UO ≤0.5 mL/kg/h × 8 h | UO <1.5 mL/kg/h for 24 h |
| | Injury | Increased creatinine x2 or GFR decreases >50% | Increased creatinine x2 or GFR decreases >50% | UO ≤0.5 mL/kg/h × 12 h | UO ≤0.5 mL/kg/h × 16 h | UO <1.0 mL/kg/h for 24 h |
| | Failure | Increased creatinine x3 or GFR decreases >75% or creatinine >4 mg/dL (acute rise of >4 mg/dL) | Increased creatinine x3 or GFR decreases >75% or GFR <35 mL/min/1.73 m2 | UO ≤0.3 mL/kg/h × 24 h or anuria × 12 h | UO ≤0.3 mL/kg/h × 24 h or anuria × 12 h | UO <0.7 mL/kg/h for 24 h or anuria for 12 h |
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