Rational Design of a Triple Reporter Gene for Multimodality Molecular Imaging
Figure 6
Demonstration of triple fusion gene vector in living subjects by microPET imaging. The same mouse demonstrated previously by optical imaging was then imaged by microPET using 18F-FEAU. Cells expressing the fusion reporter genes and DsRed1-ttk gene showed 18F-FEAU accumulation in the tumor (coronal section) (a). ROIs drawn over the sites of cell implantation of four mice were calculated and expressed as percentage of injected dose per gram of tissue (% ID/g). Each bar represents the mean ± SD () (b). n.s.: statistically nonsignificant.
