Review Article

The Prognostic Impact of High On-Treatment Platelet Reactivity with Aspirin or ADP Receptor Antagonists: Systematic Review and Meta-Analysis

Table 3

Incidence and definition of outcome appraised in the multivariate model.

Follow-up (months)Definition of outcomeIncidence of outcome

Angiolillo et al., 2007 [17]24Cardiovascular death, ACS, and stroke15.2 1st quartile
12.2 2nd quartile
12.2 3rd quartile
37.7 4th quartile

Bliden et al., 2007 [18]1
12
Death secondary to any cardiovascular cause, stroke,
myocardial infarction (ami), and target/nontarget vessel
revascularization
23 (1 month FU)
50 (12 months FU)

Breet et al., 2010 [19] 12All-cause death, nonfatal ami, stent thrombosis, and strokeLTA 5 11.3 (DHPR)
   8.8 (HAPR)
   10.9 (HCPR)
   4.1 (NPR)
LTA 20 10.7 (DHPR)
   9.6 (HAPR)
   11.7 (HCPR)
   4.2 (NPR)

Buonamici et al., 2007 [2]6Stent thrombosis3.1

Campo et al., 2010 [20]12All-cause death, nonfatal ami, and strokeFull Responder (FR) 8.6
Poor Responder (PR) 15.8
ASA FR 10 PR 13
Clop FR 5.9 PR 17.3

Chiu et al., 2011 [21]24Cardiovascular death, nonfatal myocardial infarction, or nonfatal stroke10

Collet et al., 2012 [7]1Stent thrombosis2

Cuisset et al., 2006; 300 mg [22]1Cardiovascular death, nonfatal ami, stent thrombosis, and stroke12
33.3 HPR 0.5 NPR

Cuisset et al., 2006; 600 mg [22]1Cardiovascular death, nonfatal ami, stent thrombosis, and stroke4.1
27.2 HPR 0.008 NPR

Geisler et al., 2006 [23] 3Cardiovascular death, nonfatal ami, and nonfatal stroke6.6
5.6 Adequate clopidogrel response
22.7 Low clopidogrel response

Hochholzer et al., 2006 [24]1All-cause death, nonfatal ami, and percutaneous revascularization1.9
3.5 in upper quartile

Jin et al., 2013 [25]12Cardiovascular death, nonfatal ami, and nonfatal stroke11

D.-W. Park et al., 2011 [26]12 Cardiac death and nonfatal ami1.4
0.9 Adequate clopidogrel response
2.8 Low clopidogrel response

Ko et al., 2011 [27]1All-cause death, nonfatal ami, nonfatal stroke, and percutaneous revascularization8.6

Marcucci et al., 2012 [28]12Cardiac death and nonfatal ami9.6

Motoda et al., 2012 [29]12Cardiac death, nonfatal ami, stent thrombosis, and target vessel revascularization12
19 in HPR
5.1 in NPR

K. W. Park et al., 2011 [30]24Cardiac death, nonfatal ami, nonfatal stroke, and urgent percutaneous revascularization14.6 HPR
8.7 LPR

Park et al. (ACS), 2013 [31]72Cardiac death, nonfatal ami, nonfatal stroke, urgent percutaneous revascularization, and stent thrombosis

Park et al. (Stable Angina), 2013 [31]72Cardiac death, nonfatal ami, nonfatal stroke, urgent percutaneous revascularization, and stent thrombosis

Parodi et al., 2011 [32]1Cardiac death, nonfatal ami and percutaneous revascularization3 1st quartile
5 2nd quartile
10 3rd quartile
20 4th quartile

Patti et al., 2008 [33] 24All-cause death, nonfatal ami, unstable angina, and stroke13.3 HAPR
9.9 LAPR

Pettersen et al., 2012 [34]6Cardiovascular death, nonfatal myocardial infarction, and stent thrombosis6.5 HPR
1 LPR

Price et al., 2011 [9]1Stent thrombosis2.2 HPR
0.2 LPR

Saia et al., 2013 [35]12All-cause death, ami, and urgent target vessel revascularization

Sibbing et al., 2009 [36]1All-cause death, ami, and urgent target vessel revascularizationAbciximab/UFH: 9.4 HPR 6.7 LPR
Bivalirudin: 22.0 HPR 5.0 LPR

Sibbing et al., 2012 [37]12Acute coronary syndrome, stent thrombosis, stroke, death, and revascularization37.5 DHPR
33.3 HCPR
25.6 HAPR
18.6 LPR

Siller-Matula et al., 2013 [38]Acute coronary syndrome, stent thrombosis, stroke, death, and revascularization

Stone et al., 2013 [39]24All-cause death and myocardial infarction and stent thrombosis2.4 death
3.9 mi
1.3 ST