Clinical Study
Corneal Collagen Cross-Linking with and without Epithelial Removal: A Contralateral Study with 0.5% Hypotonic Riboflavin Solution
Table 4
Changes in topography features and wavefront aberrations during 12-month follow-up.
| Parameter | CXL | Preoperative | 1 m | 6 m | 12 m |
| Pachymetry (m) | Epithelium-on | 459.50 ± 39.24 | 445.50 ± 48.92* | 453.50 ± 47.02 | 458.25 ± 41.09 | Epithelium-off | 463.05 ± 31.34 | 434.35 ± 33.90* | 434.65 ± 31.85* | 450.55 ± 32.14* | value | 0.625 | 0.286 | 0.051 | 0.273 |
| IRI (m) | Epithelium-on | 34.25 ± 18.57 | 34.35 ± 18.66 | 33.65 ± 20.16 | 35.30 ± 20.09 | Epithelium-off | 36.40 ± 13.10 | 38.05 ± 14.41 | 34.30 ± 13.91 | 33.15 ± 13.75 | value | 0.658 | 0.400 | 0.890 | 0.618 |
| PE (m) | Epithelium-on | 61.80 ± 24.90 | 62.25 ± 28.22 | 60.80 ± 24.11 | 63.00 ± 31.67 | Epithelium-off | 60.65 ± 27.01 | 59.55 ± 27.30 | 63.90 ± 25.57 | 67.35 ± 28.60 | value | 0.865 | 0.717 | 0.611 | 0.486 |
| Sim 1 (D) | Epithelium-on | 47.89 ± 4.46 | 47.75 ± 4.05 | 47.83 ± 4.59 | 47.82 ± 4.10 | Epithelium-off | 47.51 ± 2.98 | 47.52 ± 4.29 | 47.74 ± 4.43 | 47.25 ± 3.91 | value | 0.695 | 0.758 | 0.923 | 0.544 |
| Sim 2 (D) | Epithelium-on | 44.29 ± 2.77 | 44.34 ± 2.77 | 44.34 ± 2.77 | 44.47 ± 2.80 | Epithelium-off | 44.71 ± 2.98 | 44.17 ± 3.25 | 44.17 ± 33.14 | 44.01 ± 2.97 | value | 0.614 | 0.996 | 0.776 | 0.452 |
| max (D) | Epithelium-on | 52.68 ± 5.35 | 52.95 ± 5.38 | 52.40 ± 5.74 | 52.78 ± 5.55 | Epithelium-off | 53.59 ± 4.72 | 53.40 ± 5.03 | 53.58 ± 5.59 | 53.28 ± 5.18 | value | 0.525 | 0.555 | 0.620 | 0.755 |
| RMS: HOAs | Epithelium-on | 1.18 ± 0.67 | 1.20 ± 0.60 | 1.20 ± 0.71 | 1.20 ± 0.77 | Epithelium-off | 1.15 ± 0.55 | 1.15 ± 0.51 | 1.12 ± 0.57 | 1.07 ± 0.58 | value | 0.980 | 0.496 | 0.714 | 0.458 |
| RMS: S3 + 5 + 7 | Epithelium-on | 1.15 ± 0.65 | 1.16 ± 0.59 | 1.12 ± 0.71 | 1.16 ± 0.76 | Epithelium-off | 1.11 ± 0.55 | 1.03 ± 49 | 0.97 ± 0.43 | 0.99 ± 0.52 | value | 0.953 | 0.545 | 0.769 | 0.344 |
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The difference between pre- and postoperative data was statistically significant ().
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