Genistein Induces Deleterious Effects during Its Acute Exposure in Swiss Mice

Table 2

List of differentially expressed genes identified at 𝑃<0.05 and twofold change.

Gene symbol	Regulation	Group II	Group III	Group IV	Gene ontology
Sult3a1	Up	5.58	7.64	8.27	Sulfotransferase activity, transferase activity, amine sulfotransferase activity
Hamp2	Up	5.08	3.51	2.05	Killing of cells of another organism, defense response to bacterium, cellular iron ion homeostasis, extracellular region, hormone activity, defense response to fungus
Cyp4a14	Up	4.30	2.20	4.41	Oxidoreductase activity, metal ion binding, heme binding, alkane 1-monooxygenase activity, electron carrier activity, monooxygenase activity
Extl3	Up	2.79	3.55	2.53	Transferase and glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity, metal ion binding, intrinsic to endoplasmic reticulum membrane, manganese ion binding
Prei4	Up	2.36	2.19	3.99	Catalytic and hydrolase activity, glycerol-phosphodiester phosphodiesterase activity, phosphoric diester hydrolase activity, lipid, carbohydrate and glycerol metabolic process
H2-T24	Up	2.04	3.09	2.10	Molecular function, cellular component, biological process, integral to membrane
Adrbk2	Up	2.08	3.55	2.44	Protein amino acid phosphorylation, beta-adrenergic receptor kinase activity, signal transducer activity, G-protein coupled receptor and protein serine/threonine kinase activity
Gm4976	Up	2.10	3.38	2.85	Hydrolase activity
Mup20	Down	−3.43	−2.50	−4.58	Pheromone binding
Hspa1a	Down	−3.97	−4.56	−3.73	Response to stress, nucleotide binding, response to heat, cytoplasmic part, DNA repair, telomere maintenance, ATP binding
Reg3b	Down	−6.02	−2.84	−2.94	Acute-phase response, inflammatory response, sugar binding
Rps6kb1	Down	−10.12	−9.44	−10.73	Protein amino acid phosphorylation, protein kinase B signaling cascade, transferase activity and kinase activity, germ cell development
Olfr1274	Down	−10.80	−10.91	−10.32	Olfactory receptor activity, integral to membrane, sensory perception of smell, signal transducer activity, G-protein coupled receptor activity
Spn	Down	−10.55	−10.14	−9.85	Defense response to bacterium, integral to membrane, T cell costimulation, positive regulation of T cell proliferation, negative regulation of T cell proliferation, positive regulation of tumor necrosis factor biosynthetic process
Elovl3	Down	−2.66	−2.91	−3.30	Endoplasmic reticulum, fatty acid and lipid biosynthetic process, integral to membrane
Gemin6	Down	−11.48	−10.75	−11.28	Spliceosomal complex, RNA splicing, protein binding, mRNA processing