Synthesis, Characterization, and Preclinical Evaluation of New Thiazolidin-4-ones Substituted with p-Chlorophenoxy Acetic Acid and Clofibric Acid against Insulin Resistance and Metabolic Disorder

<table>Scheme for the synthesis of thiazolidin-4-ones. Reagents and conditions: (a) aromatic aldehydes, (b) methanol, (c) glacial acetic acid, reflux for 15–45 minuts, (d) dry benzene/toluene, (e) thioglycolic acid, reflux for 24–48 hrs or microwave irradiation at power setting of 80% with 3 minutes/cycle for 16 minutes, and (f) thiolactic acid.</table>

BioMed Research International

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Figure 1

Figure 1: Synthesis, Characterization, and Preclinical Evaluation of New Thiazolidin-4-ones Substituted with p-Chlorophenoxy Acetic Acid and Clofibric Acid against Insulin Resistance and Metabolic Disorder 

Figure 1 | Synthesis, Characterization, and Preclinical Evaluation of New Thiazolidin-4-ones Substituted with p-Chlorophenoxy Acetic Acid and Clofibric Acid against Insulin Resistance and Metabolic Disorder 