Preventive Effects of Dexmedetomidine on the Liver in a Rat Model of Acid-Induced Acute Lung Injury
Table 2
Levels of TAC, TOA, OSI, and MDA in serum samples (median ± interquartile range).
Groups
TAC (mmol Trolox Eq t/l)
TOA (mmolH2O2 Eq./L)
OSI (H2O2/Trolox)
MDA (m/L)
Group 1
1.75 ± 0.17
23.70 ± 3.80
14.05 ± 2.83
2.78 ± 1.18
Group 2
1.72 ± 0.10
30.20 ± 4.10
17.29 ± 4.15
3.27 ± 1.79
Group 3
1.45 ± 0.25
38.30 ± 44.50
24.07 ± 30.71
4.29 ± 0.89
Group 4
1.65 ± 0.06
26.40 ± 10.30
15.63 ± 6.32
2.76 ± 1.18
value between 4 groups (with Kruskal-Wallis one-way analysis of variance)
Groups 1–4
0.007
0.002
0.001
0.020
values of pairwise comparisons (with Mann-Whitney test)
1–3
0.004
0.001
0.001
0.011
2-3
0.007
0.026
0.002
0.040
3-4
0.015
0.004
0.007
0.011
Groups are as follows; Group 1: normal saline group; Group 2: normal saline plus ventilator (V) group; Group 3: hydrochloric acid (HCl) plus ventilator group; Group 4: HCl + V plus dexmedetomidine group. TAC: total antioxidant capacity, TOA: total oxidant activity, OSI (arbitrary units): oxidative stress index, MDA: malondialdehyde.
