Factors Determining Disease Duration in Alzheimer’s Disease: A Postmortem Study of 103 Cases Using the Kaplan-Meier Estimator and Cox Regression
Table 4
Results of the Cox proportional hazard model analysis for abundance scores of senile plaques (SP) and neurofibrillary tangles (NFT) in each brain region.
Area
SE
Wald
Superior frontal gyrus
−0.00329
0.01
0.31
0.098
0.75
Cingulate gyrus
−0.00998
0.02
0.44
0.99
0.66
Orbital gyrus
0.02039
0.01
2.03
4.12
0.04*
Gyrus rectus
−0.1717
0.03
0.62
0.98
0.53
Amygdala
0.01040
0.01
1.31
1.01
0.19
Dentate gyrus
0.00544
0.03
0.19
1.00
0.85
Insula
−0.00252
0.01
0.26
0.07
0.79
Claustrum
0.03414
0.02
1.71
2.92
0.09
Parahippocampal gyrus
−0.00190
0.01
0.17
0.03
0.86
Hippocampus CA1
0.03575
0.02
2.04
4.18
0.04*
Superior temporal gyrus
0.00699
0.01
0.74
0.55
0.46
Ventral tegmentum
0.00470
0.02
0.26
1.00
0.80
Raphe nucleus
−0.02172
0.02
1.11
1.24
0.27
Substantia nigra
0.02086
0.04
0.47
0.22
0.64
Thalamus
−0.02530
0.02
1.58
2.51
0.11
Visual cortex (B17/B18)
−0.00912
0.01
0.98
0.95
0.33
Superior parietal
−0.01378
0.01
1.42
2.02
0.15
Nucleus basalis of Meynert
0.03978
0.02
2.09
4.38
0.04*
Mamillary bodies
0.01486
0.02
0.78
0.59
0.44
Hypothalamus
0.01424
0.02
063
0.40
0.53
Basal ganglia
−0.02667
0.02
1.17
1.37
0.24
Cerebellar cortex
−0.0297
0.02
1.41
1.97
0.16
: regression coefficient; SE: standard error; : probability; .
