Preparation of Naringenin/β-Cyclodextrin Complex and Its More Potent Alleviative Effect on Choroidal Neovascularization in Rats

Figure 4

Naringenin/β-CD complex significantly inhibits the mRNA expression of key mediators involved in the pathogenesis of CNV in rats. (a)–(f) are real-time PCR analyses of transcript levels of VEGF, COX-2, PI3K, p38MAPK, MMP-2, and MMP-9. GAPDH was used as the invariant control for calculating fold changes in mRNA levels. Group 1: normal rats; group 2: CNV rats without treatment; group 3: CNV rats with naringenin treatment; group 4: CNV rats with naringenin/β-CD complex treatment. Data are expressed as mean ± SD; ^#𝑃<0.05 versus group 1, ^##𝑃<0.01 versus group 1, ^∗𝑃<0.05 versus group 2, and ^∗∗𝑃<0.01 versus group 2.

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