Current Opportunities and Challenges of Magnetic Resonance Spectroscopy, Positron Emission Tomography, and Mass Spectrometry Imaging for Mapping Cancer Metabolism In Vivo

Figure 3

Correlation of histopathology and mass spectrometry imaging. Serial sections of the tumor are used for histopathology (left) correlation with MSI results (right). Deconvolution of spectra is performed to separate 2H-labeled and unlabeled lipids. Intensity images are generated to show the spatial distribution for both newly synthesized and preexisting lipids. Reprinted with permission from [106]. Copyright 2013 Nature Publishing Group, a division of Macmillan Publishers Limited.