Activation of the AT1R/HIF-1<b><i>α</i></b>/ACE Axis Mediates Angiotensin II-Induced VEGF Synthesis in Mesenchymal Stem Cells

<div>Scheme of Ang II-driven VEGF synthesis. Ang II induction sensing via HIF-1<i>α</i> or STAT3 activates an autocrine loop of ACE upregulation, Ang II formation, and signaling via AT1R, which exerts a positive feedback and further fosters VEGF synthesis in MSCs.</div>

BioMed Research International

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Figure 5

Figure 5: Activation of the AT1R/HIF-1<b><i>α</i></b>/ACE Axis Mediates Angiotensin II-Induced VEGF Synthesis in Mesenchymal Stem Cells 

BioMed Research International

Activation of the AT1R/HIF-1α/ACE Axis Mediates Angiotensin II-Induced VEGF Synthesis in Mesenchymal Stem Cells

Figure 5