A Time-Dose Model to Quantify the Antioxidant Responses of the Oxidative Hemolysis Inhibition Assay (OxHLIA) and Its Extension to Evaluate Other Hemolytic Effectors

Table 3

Part A shows the additional parameters of interest (, , and ) and reparameterization equations deduced from algebraic modifications of (5) to make such values explicit and therefore to compute their confidence intervals. Part B shows four of the most common effector perturbations (linear, hyperbolic, sigmoidal, and bell modifications) on the kinetic description of the survival erythrocyte population.

A: Additional parameters of interest
Parameter calculation	Reparameterization form of (5)	Eq. number
		(i)
		(ii)
		(iii)
B: effector variations on the survival population
Effector relation	Model chosen to modify parameters of (5)	Eq. no.
Linear ()		(iv)
Hyperbolic ()		(v)
Sigmoidal ()		(vi)
Bell ()		(vii)

Part A: maximum rate of hemolysis (); the rate at the value (); the lag-phase (); and .
Part B: is the slope (/ units); is the intercept ( units); is the asymptotic value of the hyperbolic relation (parameter modified units); is / units; is the asymptotic value (parameter modified units) of the nonlinear relation, is the IC₅₀ value ( units); is a shape parameter related to the maximum slope of the response; is the maximum value (parameter modified units), is related to the distance between the tails of the function ( units), is a value related to the asymmetry of the bell profile, and is the effector value at which takes place ( units).