Effects of Hypertension and Exercise on Cardiac Proteome Remodelling

Table 2

Challenges and future perspectives in cardiac proteome in hypertension research.

Challenges in cardiac proteomic and hypertension research:
(i) integration of “omics” tools as a multiple strategy;
(ii) MS-based proteomics coupled with NGS approach;
(iii) proteomic and genomic large-scale studies in hypertension development and treatment;
(iv) identification of posttranslational polymorphism and genetic factors;
(v) identification of novel differential molecular signalling and expression between physiologic and pathologic cardiac hypertrophy;
(vi) identification of novel hypertension biomarkers in blood samples.
Future direction in cardiac proteome and hypertension research:
(i) novel studies cross talking proteomic and genomic data;
(ii) improvement in gene expression quantitation and transcriptome data;
(iii) identification of novel pharmacologic targets and nonpharmacologic strategies in hypertension attenuation;
(iv) novel drug design and texting in cellular and experimental hypertensive models;
(v) investigation of exercise and other alternative strategies in hypertension attenuation.

NGS: next generation sequencing.