MMSET: Role and Therapeutic Opportunities in Multiple Myeloma

Figure 1

Schematic primary structure of three major MMSET isoforms. PWWP, named for a conserved Pro-Trp-Trp-Pro motif; HMG-b, high mobility group (HMG) box domain; PHD, plant homeodomain zinc finger; AWS, associated with SET domain; and SET, lysine methyltransferase catalytic domain. Conserved domain architecture was analyzed through http://blast.ncbi.nlm.nih.gov.