Contribution of α,β-Amyrenone to the Anti-Inflammatory and Antihypersensitivity Effects of Aleurites moluccana (L.) Willd.

Figure 5

Effect of the treatment with α,β-amyrenone (7.07–70.7 μmol/kg, p.o.), dexamethasone (1.27 μmol/kg, s.c), or vehicle (10 mL/kg, 0.9% NaCl solution, p.o.) on the mechanical hypersensitivity of the (a) right and (b) left hindpaw and paw oedema induced by i.d. injection of CFA (50 μL/paw; 1 : 1 0.9% NaCl solution) into the mice right hindpaw. Zero (day zero) corresponds to baseline measurement of animals performed 24 hours before the test. Each group represents the mean of 5 to 8 animals, and the vertical lines indicate the SEM. Significantly different from saline group values ^#, and significantly different from control values , , and . Two-way ANOVA followed by Bonferroni’s post hoc test.

(a)

(b)

(c)