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BioMed Research International
Volume 2014 (2014), Article ID 637098, 10 pages
http://dx.doi.org/10.1155/2014/637098
Research Article

Apoptotic and Inhibitory Effects on Cell Proliferation of Hepatocellular Carcinoma HepG2 Cells by Methanol Leaf Extract of Costus speciosus

1Department of Environmental Sciences, Faculty of Agriculture, Dalhousie University, Truro, NS, Canada B2N 5E3
2Department of Pharmacology, Faculty of Medicine, University of Ruhuna, Karapitiya, Sri Lanka

Received 18 October 2013; Revised 1 February 2014; Accepted 4 February 2014; Published 10 April 2014

Academic Editor: Paul J. Higgins

Copyright © 2014 Sandhya V. G. Nair et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. G. L. Davis, J. Dempster, J. D. Meler et al., “Hepatocellular carcinoma: management of an increasingly common problem,” Proceedings of Baylor University Medical Center, vol. 21, pp. 266–280, 2008.
  2. R. Pang, E. Tse, and R. T. P. Poon, “Molecular pathways in hepatocellular carcinoma,” Cancer Letters, vol. 240, no. 2, pp. 157–169, 2006. View at Publisher · View at Google Scholar · View at Scopus
  3. S. Mittal and H. B. El-Serag, “Epidemiology of hepatocellular carcinoma: consider the population,” Journal of Cinical Gastroenterology, vol. 47, supplement, pp. S2–S6, 2013.
  4. T. Takayama, M. Makuuchi, S. Hirohashi et al., “Early hepatocellular carcinoma as an entity with a high rate of surgical cure,” Hepatology, vol. 28, no. 5, pp. 1241–1246, 1998. View at Publisher · View at Google Scholar · View at Scopus
  5. R. T. Poon and S. T. Fan, “Resection prior to liver transplantation for hepatocellular carcinoma: a strategy of optimizing the role of resection and transplantation in cirrhotic patients with preserved liver function,” Liver Transplantation, vol. 10, pp. 813–815, 2004.
  6. S. Garrean, J. Hering, A. Saied, W. S. Helton, and N. J. Espat, “Radiofrequency ablation of primary and metastatic liver tumors: a critical review of the literature,” American Journal of Surgery, vol. 195, no. 4, pp. 508–520, 2008. View at Publisher · View at Google Scholar · View at Scopus
  7. R. Lencioni, “Chemoembolization for hepatocellular carcinoma,” Seminars in Oncology, vol. 39, pp. 503–509, 2012.
  8. A. M. Horgan, L. A. Dawson, A. Swaminath, and J. J. Knox, “Sorafenib and radiation therapy for the treatment of advanced hepatocellular carcinoma,” Journal of Gastrointestinal Cancer, vol. 43, pp. 344–348, 2012. View at Publisher · View at Google Scholar · View at Scopus
  9. J. Furuse, “Sorafenib for the treatment of unresectable hepatocellular carcinoma,” Biologics: Targets and Therapy, vol. 2, no. 4, pp. 779–788, 2008. View at Scopus
  10. Y. Qurishi, A. Hamid, R. Majeed et al., “Interaction of natural products with cell survival and signaling pathways in the biochemical elucidation of drug targets in cancer,” Future Oncology, vol. 7, no. 8, pp. 1007–1021, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. S. Srivastava, P. Singh, K. K. Jha, G. Misha, S. Srivastava, and R. L. Khosa, “Evaluation of anti-arthitic potential of the methanolic extract of the aerial parts of Costus speciosus,” Journal of Ayurveda and Integrative Medicine, vol. 3, pp. 204–208, 2012.
  12. J. H. Bavarva and A. V. R. L. Narasimhacharya, “Antihyperglycemic and hypolipidemic effects of Costus speciosus in alloxan induced diabetic rats,” Phytotherapy Research, vol. 22, no. 5, pp. 620–626, 2008. View at Publisher · View at Google Scholar · View at Scopus
  13. M.-J. Liu, Z. Wang, Y. Ju, R. N.-S. Wong, and Q.-Y. Wu, “Diosgenin induces cell cycle arrest and apoptosis in human leukemia K562 cells with the disruption of Ca2+ homeostasis,” Cancer Chemotherapy and Pharmacology, vol. 55, no. 1, pp. 79–90, 2005. View at Publisher · View at Google Scholar · View at Scopus
  14. S. Anuchapreeda, S. Tima, C. Duangrat, and P. Limtrakul, “Effect of pure curcumin, demethoxycurcumin, and bisdemethoxycurcumin on WT1 gene expression in leukemic cell lines,” Cancer Chemotherapy and Pharmacology, vol. 62, no. 4, pp. 585–594, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. A. A. Baskar, K. S. Al Numair, M. A. Alsaif, and S. Ignacimuthu, “In vitro antioxidant and antiproliferative potential of medicinal plants used in traditional Indian medicine to treat cancer,” Redox Report, vol. 17, pp. 145–156, 2012.
  16. D. Stagos, G. D. Amougias, A. Matakos, A. Spyrou, A. M. Tsatsakis, and D. Kouretas, “Chemoprevention of liver cancer by plant polyphenols,” Food and Chemical Toxicology, vol. 50, no. 6, pp. 2155–2170, 2012. View at Publisher · View at Google Scholar · View at Scopus
  17. P. Karna, S. R. Gundala, M. V. Gupta et al., “Polyphenol-rich sweet potato greens extract inhibits proliferation and induces apoptosis in prostate cancer cells in vitro and in vivo,” Carcinogenesis, vol. 32, no. 12, pp. 1872–1880, 2011. View at Publisher · View at Google Scholar · View at Scopus
  18. K. Sak, “Chemotherapy and dietary phytochemical agents,” Chemotherapy Research and Practice, vol. 2012, Article ID 282570, 11 pages, 2012. View at Publisher · View at Google Scholar
  19. S. Srivastava, P. Singh, K. K. Jha, G. Mishra, S. Srivastava, and R. L. Khosa, “Anthelmintic activity of aerial parts of Costus speciosus,” International Journal of Green Pharmacy, vol. 5, no. 4, pp. 325–328, 2011. View at Publisher · View at Google Scholar · View at Scopus
  20. I. Paur, M. H. Carlsen, B. L. Halvorsen, and R. Blomhoff, “Chapter 2. Antioxidants in herbs and spices: roles in oxidative stress and redox signaling,” in Herbal Medicine: Biomolecular and Clinical Aspects, I. F. F. Benzie and S. Wachtel-Galor, Eds., CRC Press, Boca Raton, Fla, USA, 2011.
  21. G. Deep, M. Dhiman, A. R. Rao, and R. K. Kale, “Chemopreventive potential of Triphala (a composite Indian rug) on benzo(a)pyrene induced forestomach tumorigenesis in murine tumor model system,” Journal of Experimental & Clinical Cancer Research, vol. 24, no. 4, pp. 555–563, 2005. View at Scopus
  22. M. A. Vijayalakshmi and N. C. Sarada, “Screening of Costus speciosus extracts for antioxidant activity,” Fitoterapia, vol. 79, no. 3, pp. 197–198, 2008. View at Publisher · View at Google Scholar · View at Scopus
  23. B. Dasgupta and V. B. Pandey, “A new indian source of diosgenin (Costus speciosus),” Experientia, vol. 26, no. 5, pp. 475–476, 1970. View at Publisher · View at Google Scholar · View at Scopus
  24. D. S. Kim, B. K. Jeon, Y. E. Lee, W. H. Woo, and Y. J. Mun, “Diosgenin induces apoptosis in HepG2 cells though generation of reactive Oxygen species and mitochondrial pathway,” Evidence-Based Complementary and Alternative Medicine, vol. 2012, Article ID 981675, 8 pages, 2012. View at Publisher · View at Google Scholar