Apoptotic and Inhibitory Effects on Cell Proliferation of Hepatocellular Carcinoma HepG2 Cells by Methanol Leaf Extract of Costus speciosus

Table 2

Cytotoxic effect of methanol extract of Costus speciosus or cancer drugs (positive control) on cancer and normal cells after 24 h and 48 h of exposure.

	Cytotoxicity assay IC 50 (𝜇g/mL)
Test compounds	Human hepatocellular carcinoma HepG2 cells		Human acute monocytic leukemia cells THP-1		Normal lung cells
	24 h	48 h	24 h	48 h	24 h	48 h
Methanol extract of Costus speciosus leaves	93.3	77.3	58.1	42.2	>100	>100
Sorafenib (liver cancer drug)	3.8	0.4	—	—	—	—
Daunorubicin hydrochloride (leukemia drug)	—	—	0.6	0.4	—	—