E-Cadherin and Gastric Cancer: Cause, Consequence, and Applications

Table 1

Genetic mutations of E-cadherin (CDH1) in diffuse gastric cancer in populations.

Population	Analytical methods	Mutations/variants	References
New Zealand	SSCP and sequencing	1008G>T in exon 7	[50]
Portuguese	PCR-SSCP and sequencing	1901C>T in exon 12	[51]
Chinese	PCR-DHPLC and sequencing	2253C>T in exon 14	[52]
Italian	SSCP, PCR and sequencing	163+37235G>A variant in intron 2	[53]
Korean	PCR, sequencing, and MLPA	1003C>T in exon 7	[54]

SSCP: single stranded conformational polymorphism; PCR: polymerase chain reaction; DHPLC: denaturing high-performance liquid chromatography; MLPA: multiplex ligation-dependent probe amplification.