The Role of Uric Acid in Kidney Fibrosis: Experimental Evidences for the Causal Relationship

<table>The pathway of purine nucleotides degradation in humans showing the competitive inhibition of uric acid formation by xanthine oxidase inhibitors and the site of action. AMP: adenosine monophosphate; GMP: guanosine monophosphate; IMP: inosine monophosphate; MSU: monosodium urate; <i>①</i>: 5′-nucleotidase; <i>②</i>: AMP deaminase; <i>③</i>: adenosine deaminase; <i>④</i>: purine nucleoside phosphorylase; <i>⑤</i>: guanine deaminase.</table>

BioMed Research International

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Figure 1

Figure 1: The Role of Uric Acid in Kidney Fibrosis: Experimental Evidences for the Causal Relationship 