Saccharin Sulfonamides as Inhibitors of Carbonic Anhydrases I, II, VII, XII, and XIII
Figure 4
Isothermal titration calorimetry (ITC, 37°C) binding curves for compound 2 to CA II (panel (a), = 290 nM) and CA XIII (panel (b), = 120 nM) and saccharin (1) to CA II (panel (c), > 10−4 M, could not be accurately determined). Table 2 lists the dissociation constants obtained by ITC for the tested compounds binding to all five CAs.
