Saccharin Sulfonamides as Inhibitors of Carbonic Anhydrases I, II, VII, XII, and XIII

Figure 5

The thermodynamics of saccharin (1) and saccharin derivatives (2–4) binding to five CA isoforms, determined by FTSA at pH 7.0 and 37°C. The numbers within the shapes represent the Gibbs free energies of binding to a particular CA while the numbers on arrows show the differences in between two compounds that are most similar in chemical structure (kJ/mol). These differences represent the functional group contributions to the overall binding thermodynamics.