In Vivo Protection against Strychnine Toxicity in Mice by the Glycine Receptor Agonist Ivermectin
Figure 1
Protection against strychnine toxicity by intraperitoneal ivermectin. (a) Dosage schedule for systemic IVM administration. Group A received vehicle (DMSO, open square), groups B–D received 5 mg/kg IVM (solid circles), followed by 2 mg/k strychnine (sold triangles) after the indicated waiting period. Number of animals: A (); B (); C (); D (). (b) Survival rates of groups A–D. The values for statistical significance (Fisher’s one-tailed t-test), relative to control (group A) are given above each column. (c) Time course of survival in groups A–D.
