In Vivo Protection against Strychnine Toxicity in Mice by the Glycine Receptor Agonist Ivermectin
Figure 3
Combined effects of oral and systemic ivermectin administration. (a) Dosage schedule for combined IVM administration. All groups H–M received an oral ivermectin dose of 1 mg/kg (H–J, open circles) or 5 mg/k (L-M, open stars), followed by 5 mg/kg ip ivermectin (solid circles) after the indicated waiting times, and 2 mg/kg strychnine (solid triangles) after another 30 min (H–L) or 14 hrs (M). Number of animals: H (); I (); J (); K (); L (); M (). (b) Survival rates of groups H–M. For comparison, survival rates of control groups A (vehicle only) and B (5 mg/kg ivermectin only) are also shown. The values for statistical significance (Fisher’s one-tailed t-test), relative to control (group A), are given above each column. (c) Time course of survival in groups H–J (left panel) and K–M (right panel). Survival curves for control groups A and B are added for comparison. (d) Direct comparison of protective effects of a second dose of ivermectin after waiting times of 14 and 24 hours.
