Gene Delivery Potential of Biofunctional Carbonate Apatite Nanoparticles in Lungs

Figure 6

BALB/c mice lung and trachea luciferase reporter gene expression analysis. (a) Gene delivery efficiency of various formulations of CO₃Ap with constant amount of pDNA (10 μg). (b) Increasing pDNA study using 10–100 μg of pDNA with constant amount of CO₃Ap (8 μl). (c) Time point experiment utilizing 40 μg of pDNA with constant amount CO₃Ap (8 μl). Luciferase expression was measured as RLU/mg protein. The error bar represents standard error of the mean (SEM) for all data sets. The result is considered to be statistically significant if 𝑃 values were <0.05. Data are presented as mean ± S.E.M from 6 animals.

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