Ruscogenin Ameliorates Experimental Nonalcoholic Steatohepatitis via Suppressing Lipogenesis and Inflammatory Pathway

Table 3

Effects of ruscogenin on scores for hepatic steatosis and necroinflammation of hamsters.

	RCD-fed	HFD-fed
	Vehicle	Vehicle	Ruscogenin (3.0 mg/kg/day)
Steatosis (scores 0–4)	0 ± 0^d	3.1 ± 0.6^b	1.7 ± 0.3^b,d
Necroinflammation (scores 0–3)	0 ± 0^d	1.1 ± 0.3^b	0.6 ± 0.2^b,c

The vehicle (distilled water) used to prepare the tested medication solution was given at the same volume. Values (mean ± SEM) were obtained from each group of 8 animals after 8 weeks of the experimental period. ^a𝑃<0.05 and ^b𝑃<0.01 compared to the values of vehicle-treated RCD-fed hamsters in each group, respectively. ^c𝑃<0.05 and ^d𝑃<0.01 compared to the values of vehicle-treated HFD-fed hamsters in each group, respectively.