IDH1/IDH2 but Not TP53 Mutations Predict Prognosis in Bulgarian Glioblastoma Patients

Table 3

Univariate and multivariate Cox analyses of the association between the features of the patients and overall survival.

	Univariate Cox regression			Multivariate Cox regression
	HR	95% CI	P	HR	95% CI	P
Age (per year)	1.048	1.029–1.067	<0.001	1.039	1.018–1.061	<0.001
Gender (female versus male)	0.884	0.575–1.361	0.576	*	*	*
Secondary versus primary GBM	0.271	0.123–0.597	0.001	0.487	0.215–1.106	0.086
Resection (total versus others)	0.854	0.559–1.303	0.463	*	*	*
KPS (per 10 points)	0.990	0.979–1.001	0.083	*	*	*
IDH1/IDH2 (mutated versus nonmutated)	0.274	0.124–0.604	0.001	0.237	0.157–0.791	0.011
IDH1 SNP (SNP versus no SNP)	0.745	0.343–1.617	0.456	*	*	*
TP53 (mutated versus nonmutated)	0.764	0.489–1.196	0.240	*	*	*

∗Not included in multivariate analysis.
HR: hazard ratio; CI: confidence interval; P: P value; IDH1 SNP refers to rs11554137.